ARL14

Across TCGA patient cohorts, ARL14 mutation is significantly associated with the RNA expression of many other genes, with 2,001 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL14-associated genes across cancer lineages are BNIP3P41, RNA5SP172, and MIR4804. Each is linked with ARL14 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARL14-to-partner and partner-to-ARL14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P41 grouped by ARL14-low versus ARL14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL14→partner) and Y-score (partner→ARL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P41 →	+0.012	+4.308	<.001	.003	3	3
HNSC	RNA5SP172 →	+0.293	+5.015	.001	.009	3	2
HNSC	MIR4804 →	+0.900	+5.069	<.001	.008	3	2
UCEC	NDUFAF2 →	+0.620	+3.169	<.001	<.001	3	2
UCEC	RMDN1 →	+0.366	+3.212	.005	<.001	3	2
UCEC	RNA5SP222 →	+0.216	+3.374	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,001 associations by consensus.

BNIP3P41 by ARL14 expression — UCEC

Explore this box plot interactively →