ARL14

Across TCGA pan-cancer cohorts, ARL14 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ARL14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ARL14 RNA is repressed in tumor relative to normal tissue. In most cancer types ARL14 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where ARL14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−3.171	<.001	11	view →
LUAD	All	II,III,IV	+1.589	<.001	9	view →
KIRC	All	III,IV	−0.750	<.001	9	view →
HNSC	Female	IV	+2.271	.003	7	view →
READ	All	All	−2.921	<.001	5	view →
LUSC	Male	All	+1.139	<.001	5	view →
PAAD	All	All	+3.339	.009	4	view →
BRCA	Female	All	+0.154	<.001	4	view →
CHOL	All	All	+4.042	<.001	3	view →
STAD	All	IV	−2.396	.029	2	view →
THCA	Female	All	−1.284	<.001	2	view →
PRAD	All	All	−0.312	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ARL14–COAD

Open the COAD breakdown →