ARL14

Across TCGA patient cohorts, ARL14 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL14-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and eIF4E. Each is linked with ARL14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL14-to-partner and partner-to-ARL14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ARL14-low versus ARL14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL14→partner) and Y-score (partner→ARL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.267	+2.321	.016	.006	3	2
UCEC	EGFR_pY1068 →	-0.247	-1.807	.017	.027	3	1
UCEC	eIF4E →	+0.231	+2.321	.007	.006	3	1
UCEC	ACC1 →	+0.304	+2.183	.043	.033	3	1
UCEC	IGFBP2 →	-0.882	-2.459	<.001	.018	3	1
UCEC	MEK1 →	+0.406	+2.321	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

4E-BP1 by ARL14 expression — UCEC

Explore this box plot interactively →