ARL13B

Across TCGA patient cohorts, ARL13B mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL13B-associated genes across cancer lineages are PKC-delta_pS664, PKC-b-II_pS660, and RAD51. Each is linked with ARL13B in more than 2 cancer types. Because this analysis shows association rather than direction, both ARL13B-to-partner and partner-to-ARL13B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by ARL13B-low versus ARL13B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL13B→partner) and Y-score (partner→ARL13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.102	-3.321	.040	.009	3	3
UCEC	PKC-b-II_pS660 →	-0.231	-2.000	.043	.030	3	2
UCEC	RAD51 →	+0.138	+3.321	.016	.010	3	2
UCEC	CDK1 →	+0.182	+3.013	.003	.018	3	2
UCEC	Cyclin-D1 →	+0.198	+2.321	.002	.034	3	2
UCEC	eEF2 →	+0.456	+3.321	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PKC-delta_pS664 by ARL13B expression — UCEC

Explore this box plot interactively →