ARL13B

Across TCGA pan-cancer cohorts, ARL13B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ARL13B data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ARL13B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ARL13B expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, LGG, and BLCA are the cancer types where ARL13B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.676	0.502	<.001	85	view →
LGG	OS	Median	All	0.753	0.871	<.001	45	view →
BLCA	DFS	Tertile	II,III,IV	0.424	0.559	.015	40	view →
KICH	DFS	Median	II,III,IV	0.575	0.920	.006	35	view →
SKCM	OS	Median	III,IV	0.491	0.299	.005	32	view →
UCS	DFS	Tertile	IV	0.936	0.239	.024	24	view →
BRCA	DFS	Quartile	III,IV	0.931	0.790	.006	22	view →
LUSC	DFS	Tertile	III,IV	0.163	0.853	.003	18	view →
ACC	DFS	Median	All	0.425	0.729	.001	17	view →
THYM	DFS	Median	II,III,IV	0.947	0.487	.003	16	view →
SCLC	DFS	Median	II,III,IV	0.476	0.151	.006	13	view →
LIHC	OS	Median	All	0.727	0.821	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ARL13B–KIRC (DFS)

Open the KIRC breakdown →