ARL13A

Across TCGA patient cohorts, ARL13A mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL13A-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and INPP4B. Each is linked with ARL13A in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL13A-to-partner and partner-to-ARL13A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ARL13A-low versus ARL13A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL13A→partner) and Y-score (partner→ARL13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.256	-2.459	.007	.019	3	1
UCEC	FoxM1 →	+0.257	+2.087	.009	.005	3	1
UCEC	INPP4B →	-0.260	-2.459	.035	.018	3	1
UCEC	JNK2 →	+0.172	+2.087	.024	.005	3	1
UCEC	Notch1 →	+0.201	+2.128	<.001	.009	3	1
UCEC	p27_pT198 →	+0.080	+2.321	.049	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by ARL13A expression — UCEC

Explore this box plot interactively →