ARL13A

Across TCGA pan-cancer cohorts, ARL13A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ARL13A data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ARL13A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARL13A expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

KIRC, THCA, and UVM are the cancer types where ARL13A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.157	0.520	.001	58	view →
THCA	OS	Tertile	II,III,IV	0.877	1.000	.005	32	view →
UVM	DFS	Tertile	All	0.384	0.848	.006	31	view →
SKCM	OS	Median	IV	0.829	0.311	.003	28	view →
HNSC	DFS	Quartile	II,III,IV	0.486	0.313	.006	28	view →
KIRP	DFS	Tertile	IV	0.039	0.622	.021	24	view →
SCLC	OS	Median	III,IV	0.484	0.183	.021	22	view →
UCS	DFS	Tertile	IV	0.978	0.488	.024	18	view →
ACC	OS	Quartile	IV	0.844	0.339	.006	18	view →
LGG	OS	Tertile	All	0.738	0.916	.002	17	view →
KICH	OS	Tertile	All	0.827	0.963	.022	16	view →
STAD	DFS	Tertile	IV	0.305	0.743	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ARL13A–KIRC (DFS)

Open the KIRC breakdown →