ARL11

Across TCGA patient cohorts, ARL11 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL11-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and GAPDH. Each is linked with ARL11 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARL11-to-partner and partner-to-ARL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARL11-low versus ARL11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL11→partner) and Y-score (partner→ARL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.233	+2.593	<.001	.006	3	3
UCEC	EGFR_pY1068 →	-0.279	-2.662	.003	<.001	3	2
UCEC	GAPDH →	+0.446	+1.874	.026	.049	3	2
UCEC	PCNA →	+0.250	+2.222	.002	.010	3	2
COAD	ASNS →	+0.589	+3.459	<.001	.005	3	2
COAD	eEF2 →	+0.284	+3.169	.021	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by ARL11 expression — COAD

Explore this box plot interactively →