ARL11

Across TCGA pan-cancer cohorts, ARL11 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ARL11 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ARL11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ARL11 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, UVM, and LGG are the cancer types where ARL11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.428	0.261	<.001	77	view →
UVM	OS	Quartile	All	0.449	0.773	.012	52	view →
LGG	OS	Median	All	0.382	0.516	<.001	45	view →
BLCA	OS	Quartile	III,IV	0.445	0.698	.004	27	view →
LIHC	OS	Median	III,IV	0.356	0.662	.001	18	view →
KIRC	DFS	Median	II,III,IV	0.831	0.675	.028	16	view →
GBM	DFS	Tertile	All	0.168	0.427	.001	14	view →
ACC	DFS	Median	All	0.706	0.398	.014	13	view →
THCA	DFS	Quartile	II,III,IV	0.890	0.446	.009	12	view →
BRCA	OS	Median	II,III,IV	0.891	0.931	.010	10	view →
CHOL	DFS	Tertile	III,IV	0.751	0.154	.024	9	view →
STAD	DFS	Quartile	All	0.285	0.611	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ARL11–SKCM (OS)

Open the SKCM breakdown →