Across TCGA pan-cancer cohorts, ARID5A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ARID5A data layer compared with 7 for mutation status.
The strongest signal is observed in uveal melanoma (UVM), where higher ARID5A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ARID5A expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.
UVM, SKCM, and CESC are the cancer types where ARID5A RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.