ARID4A

Across TCGA patient cohorts, ARID4A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARID4A-associated genes across cancer lineages are Akt_pS473, eEF2, and 14-3-3_beta. Each is linked with ARID4A in more than 2 cancer types. Because this analysis shows association rather than direction, both ARID4A-to-partner and partner-to-ARID4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by ARID4A-low versus ARID4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID4A→partner) and Y-score (partner→ARID4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+0.413	+1.247	.044	.041	3	3
LUSC	eEF2 →	+0.201	+2.816	.045	.036	3	2
UCEC	14-3-3_beta →	-0.101	-1.899	<.001	.004	3	2
UCEC	GAPDH →	+0.377	+1.765	.014	.011	3	2
UCEC	Akt_pT308 →	+0.435	+1.999	.016	.008	3	2
UCEC	PARP_cleaved →	-0.181	-1.514	.041	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Akt_pS473 by ARID4A expression — UCEC

Explore this box plot interactively →