ARID4A

Across TCGA cell cohorts, ARID4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,930 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARID4A-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Vesicle tethering, and Negative regulation of myoblast fusion. Each is linked with ARID4A in more than 17 cancer types. Because this analysis shows association rather than direction, both ARID4A-to-partner and partner-to-ARID4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by ARID4A-low versus ARID4A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID4A→partner) and Y-score (partner→ARID4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.089	+0.818	<.001	<.001	3	18
OESOPHAGUS	Vesicle tethering →	+0.085	+0.725	.007	.004	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.102	+0.720	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mRNA metabolic process →	+0.078	+1.034	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.098	+0.714	<.001	<.001	3	16
BREAST	Mitotic cytokinesis →	+0.094	+0.610	<.001	.007	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,930 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by ARID4A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →