ARID4A

Across TCGA cell cohorts, ARID4A mutation is significantly associated with the RNA expression of many other genes, with 550 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARID4A-associated genes across cancer lineages are C5orf46, C2orf73, and EIF3L. Each is linked with ARID4A in more than 1 cancer types. Because this analysis shows association rather than direction, both ARID4A-to-partner and partner-to-ARID4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf46 grouped by ARID4A-low versus ARID4A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID4A→partner) and Y-score (partner→ARID4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C5orf46 →	+0.076	+3.843	<.001	.007	3	1
LUNG_NSCLC_LUAD	C2orf73 →	+0.100	+3.263	.001	.009	3	1
LARGE_INTESTINE	EIF3L →	+0.514	+3.257	.001	.002	3	1
LARGE_INTESTINE	CCDC134 →	+0.643	+3.131	.003	.008	3	1
LARGE_INTESTINE	CENPM →	+0.671	+3.321	.002	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.486	+3.330	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 550 associations by consensus.

C5orf46 by ARID4A expression — BLOOD_Lymphoma

Explore this box plot interactively →