ARID1A

Across TCGA cell cohorts, ARID1A mutation is significantly associated with the RNA expression of many other genes, with 2,874 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARID1A-associated genes across cancer lineages are MED18, NEIL2, and ZNF286B. Each is linked with ARID1A in more than 3 cancer types. Because this analysis shows association rather than direction, both ARID1A-to-partner and partner-to-ARID1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED18 grouped by ARID1A-low versus ARID1A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID1A→partner) and Y-score (partner→ARID1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MED18 →	+0.535	+3.000	.002	.009	3	4
LARGE_INTESTINE	NEIL2 →	+0.929	+3.212	<.001	<.001	3	4
LARGE_INTESTINE	ZNF286B →	+0.848	+2.129	<.001	.001	3	4
LARGE_INTESTINE	RIMS3 →	+0.508	+2.584	.005	.002	3	4
LARGE_INTESTINE	LCORL →	+0.346	+2.067	.008	.004	3	4
PANCREAS	RPL26 →	+0.885	+3.169	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,874 associations by consensus.

MED18 by ARID1A expression — URINARY_TRACT

Explore this box plot interactively →