ARHGEF9-IT1

Across TCGA patient cohorts, ARHGEF9-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,112 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible ARHGEF9-IT1-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', and Negative regulation of mRNA processing. Each is linked with ARHGEF9-IT1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ARHGEF9-IT1-to-partner and partner-to-ARHGEF9-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by ARHGEF9-IT1-low versus ARHGEF9-IT1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF9-IT1→partner) and Y-score (partner→ARHGEF9-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of RNA splicing →	+0.062	+0.129	<.001	<.001	3	15
STAD	Obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' →	+0.036	+0.080	<.001	<.001	3	14
STAD	Negative regulation of mRNA processing →	+0.061	+0.130	<.001	<.001	3	14
STAD	Regulation of telomere maintenance →	+0.044	+0.079	<.001	<.001	3	14
STAD	DNA biosynthetic process →	+0.043	+0.077	<.001	<.001	3	13
STAD	Positive regulation of chromosome organization →	+0.061	+0.136	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,112 associations by consensus.

Negative regulation of RNA splicing by ARHGEF9-IT1 expression — STAD

Explore this box plot interactively →