ARHGEF9-IT1

Across TCGA pan-cancer cohorts, ARHGEF9-IT1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ARHGEF9-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ARHGEF9-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ARHGEF9-IT1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KIRC, MESO, and DLBC are the cancer types where ARHGEF9-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.545	0.687	<.001	135	view →
MESO	OS	Quartile	III,IV	0.120	0.635	.001	40	view →
DLBC	OS	Tertile	II,III,IV	0.520	1.000	.003	34	view →
CHOL	DFS	Quartile	III,IV	0.082	0.753	.008	33	view →
BLCA	OS	Median	III,IV	0.610	0.467	.002	29	view →
ACC	DFS	Tertile	All	0.337	0.713	.001	23	view →
SKCM	OS	Tertile	II,III,IV	0.968	0.810	.007	21	view →
BRCA	OS	Tertile	IV	0.333	0.657	.016	18	view →
KIRP	OS	Tertile	IV	0.111	0.503	<.001	18	view →
THYM	DFS	Tertile	II,III,IV	0.830	0.966	.016	14	view →
LUAD	DFS	Quartile	IV	0.682	0.267	.033	10	view →
LGG	OS	Tertile	All	0.737	0.824	.029	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ARHGEF9-IT1–KIRC (OS)

Open the KIRC breakdown →