ARHGEF7-IT1

Across TCGA pan-cancer cohorts, ARHGEF7-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated ARHGEF7-IT1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher ARHGEF7-IT1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ARHGEF7-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UCS, BLCA, and KIRC are the cancer types where ARHGEF7-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.638	0.138	<.001	86	view →
BLCA	DFS	Tertile	All	0.482	0.636	.003	66	view →
KIRC	DFS	Quartile	All	0.865	0.775	.004	57	view →
KIRP	DFS	Tertile	IV	0.162	0.546	.009	36	view →
LUAD	DFS	Tertile	IV	0.370	0.702	.045	18	view →
UCEC	DFS	Tertile	All	0.505	0.657	.017	18	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
DLBC	DFS	Tertile	III,IV	0.137	0.790	<.001	18	view →
PAAD	DFS	Quartile	All	0.432	0.229	.004	18	view →
LGG	OS	Tertile	All	0.949	0.815	<.001	17	view →
COAD	DFS	Tertile	All	0.941	0.770	.009	15	view →
THCA	DFS	Tertile	All	0.939	0.806	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

ARHGEF7-IT1–UCS (DFS)

Open the UCS breakdown →