ARHGEF7-IT1

Across TCGA pan-cancer cohorts, ARHGEF7-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ARHGEF7-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ARHGEF7-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGEF7-IT1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and KIRP are the cancer types where ARHGEF7-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGEF7-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.123	<.001	7	view →
BRCA	All	III,IV	−0.170	<.001	6	view →
KIRP	Male	All	−0.081	<.001	6	view →
THCA	All	All	−0.043	.001	4	view →
KIRC	Male	II,III,IV	−0.061	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ARHGEF7-IT1–KICH

Open the KICH breakdown →