ARHGEF7-AS2

Across TCGA pan-cancer cohorts, ARHGEF7-AS2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ARHGEF7-AS2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ARHGEF7-AS2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ARHGEF7-AS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, DLBC, and SKCM are the cancer types where ARHGEF7-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.462	0.277	.005	61	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	52	view →
SKCM	DFS	Tertile	III,IV	0.733	0.210	<.001	51	view →
UCS	DFS	Median	II,III,IV	0.553	0.134	<.001	48	view →
LGG	OS	Median	All	0.527	0.382	<.001	47	view →
KIRP	OS	Median	All	0.936	0.831	.001	47	view →
UVM	DFS	Tertile	III,IV	0.172	0.711	.016	27	view →
STAD	DFS	Quartile	All	0.452	0.586	.014	22	view →
ACC	DFS	Quartile	III,IV	0.300	0.711	.004	21	view →
LIHC	DFS	Median	All	0.418	0.200	.002	20	view →
SARC	DFS	Tertile	All	0.678	0.458	.008	16	view →
PAAD	DFS	Median	All	0.357	0.196	.020	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ARHGEF7-AS2–HNSC (DFS)

Open the HNSC breakdown →