ARHGEF7-AS2

Across TCGA pan-cancer cohorts, ARHGEF7-AS2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARHGEF7-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ARHGEF7-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGEF7-AS2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LUAD are the cancer types where ARHGEF7-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGEF7-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.360	<.001	10	view →
KIRP	All	IV	−0.260	<.001	9	view →
LUAD	All	All	−0.052	<.001	8	view →
BRCA	All	II,III,IV	−0.436	<.001	6	view →
KIRC	Male	II,III,IV	−0.131	<.001	5	view →
UCEC	All	All	−0.173	.019	2	view →
LUSC	Male	II,III,IV	−0.084	.004	2	view →
READ	All	All	−0.072	.016	2	view →
HNSC	Male	All	−0.045	.015	2	view →
LIHC	All	All	+0.112	.017	1	view →
COAD	All	All	−0.018	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ARHGEF7-AS2–KICH

Open the KICH breakdown →