ARHGEF6

Across TCGA cell cohorts, ARHGEF6 mutation is significantly associated with the mutation status of many other genes, with 3,104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF6-associated genes across cancer lineages are CNKSR2, TRPA1, and IGF1R. Each is linked with ARHGEF6 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGEF6-to-partner and partner-to-ARHGEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNKSR2 grouped by ARHGEF6-low versus ARHGEF6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF6→partner) and Y-score (partner→ARHGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CNKSR2 →	+2.981	+3.266	.009	.009	1	5
LARGE_INTESTINE	TRPA1 →	+2.215	+3.247	.003	.003	1	5
BLOOD_Lymphoma	IGF1R →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	STRIP1 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Leukemia	DCAF1 →	+5.083	+3.672	.001	.001	1	4
BLOOD_Leukemia	PHIP →	+3.498	+3.498	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,104 associations by consensus.

CNKSR2 by ARHGEF6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →