ARHGEF40

Across TCGA pan-cancer cohorts, ARHGEF40 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ARHGEF40 data layer compared with 25 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ARHGEF40 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ARHGEF40 expression acts as an unfavorable survival marker.

UCEC, HNSC, and LSCC are the cancer types where ARHGEF40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.311	1.000	.001	28	view →
HNSC	OS	Median	IV	0.630	0.830	.028	4	view →
LSCC	OS	Median	II,III,IV	0.901	1.000	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ARHGEF40–UCEC (OS)

Open the UCEC breakdown →