ARHGEF4

Across TCGA pan-cancer cohorts, ARHGEF4 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ARHGEF4 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ARHGEF4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGEF4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

HNSC, UCEC, and DLBC are the cancer types where ARHGEF4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.129	0.697	<.001	37	view →
UCEC	DFS	Median	All	0.946	0.826	.019	28	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
BLCA	OS	Median	III,IV	0.264	0.691	<.001	14	view →
SKCM	OS	Median	All	0.552	0.877	<.001	9	view →
CESC	DFS	Median	II,III,IV	0.146	0.705	.010	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	OS	Median	II,III,IV	0.090	0.677	<.001	6	view →
SARC	DFS	Median	All	0.006	0.591	<.001	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
COAD	OS	Median	All	1.000	0.860	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ARHGEF4–HNSC (DFS)

Open the HNSC breakdown →