ARHGEF4

Across TCGA pan-cancer cohorts, ARHGEF4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARHGEF4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARHGEF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARHGEF4 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, THCA, and LUSC are the cancer types where ARHGEF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGEF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.053	<.001	10	view →
THCA	Male	All	−1.077	<.001	9	view →
LUSC	Male	II,III,IV	+1.655	<.001	8	view →
UCEC	All	III,IV	−1.894	<.001	6	view →
BRCA	All	III,IV	−1.269	<.001	6	view →
LUAD	Female	All	−0.833	<.001	5	view →
KICH	Female	All	−0.559	<.001	5	view →
KIRC	Male	All	−0.318	<.001	5	view →
STAD	Female	All	−1.778	.032	2	view →
CHOL	All	All	+0.869	.007	2	view →
PRAD	All	All	−0.669	<.001	2	view →
READ	Female	All	−1.755	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARHGEF4–HNSC

Open the HNSC breakdown →