ARHGEF4

Across TCGA patient cohorts, ARHGEF4 RNA expression is significantly associated with the RNA expression of many other genes, with 16,689 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible ARHGEF4-associated genes across cancer lineages are HDAC4, SPEG, and NCS1. Each is linked with ARHGEF4 in more than 27 cancer types. Because this analysis shows association rather than direction, both ARHGEF4-to-partner and partner-to-ARHGEF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF4 versus HDAC4 in SCLC, with a Pearson correlation of 0.39.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF4→partner) and Y-score (partner→ARHGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	HDAC4 →	+0.975	+1.195	<.001	.004	2	28
SARC	SPEG →	+1.705	+0.954	<.001	<.001	3	26
ESCA	NCS1 →	+1.576	+2.398	<.001	<.001	3	25
SARC	SLC4A3 →	+1.712	+1.450	<.001	<.001	3	25
ESCA	SEPTIN5 →	+1.719	+2.491	<.001	<.001	3	24
ESCA	GPC1 →	+2.410	+2.589	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,689 associations by consensus.

ARHGEF4 vs HDAC4 — SCLC

Explore this scatter interactively →