ARHGEF4

Across TCGA patient cohorts, ARHGEF4 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,706 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARHGEF4-associated proteins across cancer lineages are DDAH1, DSP_S176, and KRT5_T24. Each is linked with ARHGEF4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGEF4-to-partner and partner-to-ARHGEF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF4 versus DDAH1 in BRCA, with a Pearson correlation of -0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF4→partner) and Y-score (partner→ARHGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDAH1 →	-0.552	-0.728	<.001	<.001	3	5
LSCC	DSP_S176 →	+1.367	+1.502	<.001	<.001	3	5
PDAC	KRT5_T24 →	+1.960	+0.928	.006	.006	3	5
BRCA	SERPINB5 →	+1.073	+0.869	<.001	<.001	3	5
LSCC	BICD2 →	+0.609	+1.091	<.001	<.001	3	5
CCRCC	PHKB_S27 →	-0.994	-0.252	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,706 associations by consensus.

ARHGEF4 vs DDAH1 — BRCA

Explore this scatter interactively →