ARHGEF4

Across TCGA patient cohorts, ARHGEF4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,710 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ARHGEF4-associated genes across cancer lineages are GRHL3, GAST, and CD40. Each is linked with ARHGEF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF4-to-partner and partner-to-ARHGEF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF4 versus GRHL3 in LSCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF4→partner) and Y-score (partner→ARHGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GRHL3 →	+1.534	+0.857	<.001	.001	3	3
HNSC	GAST →	+1.314	+0.468	<.001	.001	3	3
HNSC	CD40 →	-0.652	-0.273	<.001	.003	3	2
LSCC	EMC2 →	+0.295	+0.595	.003	.008	3	2
GBM	MGP →	-1.288	-0.392	.002	.001	3	2
HNSC	BMP5 →	-1.082	-0.383	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,710 associations by consensus.

ARHGEF4 vs GRHL3 — LSCC

Explore this scatter interactively →