ARHGEF4

Across TCGA patient cohorts, ARHGEF4 mutation is significantly associated with the RNA expression of many other genes, with 4,399 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF4-associated genes across cancer lineages are KNL1, ADI1, and LINC02824. Each is linked with ARHGEF4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF4-to-partner and partner-to-ARHGEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNL1 grouped by ARHGEF4-low versus ARHGEF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF4→partner) and Y-score (partner→ARHGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KNL1 →	+0.627	+2.627	<.001	<.001	3	4
UCEC	ADI1 →	+0.264	+1.394	.003	.008	3	4
BRCA	LINC02824 →	+0.047	+4.026	.007	.002	3	3
UCEC	USP14 →	+0.346	+1.898	.002	.001	3	3
UCEC	RBBP8 →	+0.702	+3.534	<.001	<.001	3	3
UCEC	PLEKHJ1 →	+0.454	+1.595	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,399 associations by consensus.

KNL1 by ARHGEF4 expression — UCEC

Explore this box plot interactively →