ARHGEF4

Across TCGA cell cohorts, ARHGEF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,786 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF4-associated GO terms across cancer lineages are RNA export from nucleus, Cytoplasmic translation, and Regulation of mRNA splicing, via spliceosome. Each is linked with ARHGEF4 in more than 10 cancer types. Because this analysis shows association rather than direction, both ARHGEF4-to-partner and partner-to-ARHGEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA export from nucleus grouped by ARHGEF4-low versus ARHGEF4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF4→partner) and Y-score (partner→ARHGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNA export from nucleus →	+0.131	+2.240	<.001	<.001	3	11
STOMACH	Cytoplasmic translation →	+0.069	+1.883	<.001	<.001	3	11
STOMACH	Regulation of mRNA splicing, via spliceosome →	+0.098	+2.510	.004	<.001	3	10
STOMACH	Nuclear export →	+0.088	+2.057	.003	.004	3	10
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.163	+2.895	<.001	<.001	3	10
PANCREAS	Regulation of protein localization to nucleus →	+0.093	+1.796	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,786 associations by consensus.

RNA export from nucleus by ARHGEF4 expression — STOMACH

Explore this box plot interactively →