ARHGEF4

Across TCGA cell cohorts, ARHGEF4 mutation is significantly associated with the RNA expression of many other genes, with 659 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF4-associated genes across cancer lineages are DEPDC1, CEACAM21, and SPRR1A. Each is linked with ARHGEF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF4-to-partner and partner-to-ARHGEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC1 grouped by ARHGEF4-low versus ARHGEF4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF4→partner) and Y-score (partner→ARHGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEPDC1 →	+0.880	+3.364	<.001	.002	3	2
OESOPHAGUS	CEACAM21 →	+0.057	+4.392	<.001	.003	3	1
OVARY	SPRR1A →	+0.945	+4.228	<.001	.006	3	1
LUNG_NSCLC_LUAD	MYH1 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	RXFP2 →	+0.054	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	DEFA4 →	+0.019	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 659 associations by consensus.

DEPDC1 by ARHGEF4 expression — LARGE_INTESTINE

Explore this box plot interactively →