ARHGEF39

Across TCGA patient cohorts, ARHGEF39 mutation is significantly associated with the RNA expression of many other genes, with 285 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF39-associated genes across cancer lineages are ACTR3BP6, RN7SL398P, and SSX2B. Each is linked with ARHGEF39 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF39-to-partner and partner-to-ARHGEF39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTR3BP6 grouped by ARHGEF39-low versus ARHGEF39-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF39→partner) and Y-score (partner→ARHGEF39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ACTR3BP6 →	+0.029	+7.954	<.001	.008	3	2
CESC	RN7SL398P →	+0.165	+5.306	<.001	.006	3	2
CESC	SSX2B →	+0.054	+5.669	<.001	.003	3	2
COAD	TRGJP1 →	+1.490	+4.754	<.001	.003	3	2
COAD	OR13Z3P →	+0.177	+4.790	.004	.006	3	2
BRCA	MTND4P8 →	+0.033	+5.540	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 285 associations by consensus.

ACTR3BP6 by ARHGEF39 expression — HNSC

Explore this box plot interactively →