Across TCGA patient cohorts, ARHGEF28 mutation is significantly associated with the RNA expression of many other genes, with 3,124 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF28-associated genes across cancer lineages are RN7SL267P, HMGB3P3, and RNU6-993P. Each is linked with ARHGEF28 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF28-to-partner and partner-to-ARHGEF28 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF28→partner) and Y-score (partner→ARHGEF28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SL267P →	+0.232	+5.149	<.001	.007	3	3
READ	HMGB3P3 →	+0.087	+5.257	<.001	.002	3	3
HNSC	RNU6-993P →	+0.317	+4.505	<.001	.009	3	3
UCEC	UBE2L3 →	+0.284	+1.901	<.001	<.001	3	3
UCEC	SYNJ2BP-COX16 →	+0.148	+2.143	.001	<.001	3	3
UCEC	BAG3 →	+0.350	+1.280	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,124 associations by consensus.

Exploration

ARHGEF28 survival (RNA) · tumor vs normal (RNA) · all ARHGEF28 data types