Across TCGA patient cohorts, ARHGEF28 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF28-associated genes across cancer lineages are eEF2, GAPDH, and Shc_pY317. Each is linked with ARHGEF28 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF28-to-partner and partner-to-ARHGEF28 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF28→partner) and Y-score (partner→ARHGEF28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.294	+1.502	.003	.025	3	4
UCEC	GAPDH →	+0.334	+1.678	.025	.019	3	3
UCEC	Shc_pY317 →	-0.173	-1.893	<.001	<.001	3	3
UCEC	TFRC →	+0.392	+1.906	.007	.014	3	3
UCEC	ASNS →	+0.251	+1.584	.012	.008	3	3
UCEC	ATM →	-0.496	-1.678	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

ARHGEF28 survival (RNA) · tumor vs normal (RNA) · all ARHGEF28 data types