Across TCGA cell cohorts, ARHGEF28 mutation is significantly associated with the drug of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF28-associated genes across cancer lineages are WYE-125132, IMD-0354, and CCT007093. Each is linked with ARHGEF28 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF28-to-partner and partner-to-ARHGEF28 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF28→partner) and Y-score (partner→ARHGEF28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WYE-125132 →	+0.685	+2.874	.003	.021	3	2
BREAST	IMD-0354 →	+0.449	+2.643	.044	.048	3	1
LARGE_INTESTINE	CCT007093 →	+0.310	+2.649	.037	.046	3	1
LARGE_INTESTINE	Niraparib →	+0.406	+2.868	.015	.022	3	1
LARGE_INTESTINE	Fulvestrant →	+0.379	+2.871	.019	.021	3	1
LARGE_INTESTINE	123829 →	+0.684	+2.871	.012	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

ARHGEF28 survival (RNA) · tumor vs normal (RNA) · all ARHGEF28 data types