ARHGEF17

Across TCGA patient cohorts, ARHGEF17 mutation is significantly associated with the RNA expression of many other genes, with 4,208 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ARHGEF17-associated genes across cancer lineages are PSMB6, MRPS27, and CENPK. Each is linked with ARHGEF17 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGEF17-to-partner and partner-to-ARHGEF17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by ARHGEF17-low versus ARHGEF17-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF17→partner) and Y-score (partner→ARHGEF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMB6 →	+0.499	+1.920	<.001	.009	3	4
COAD	MRPS27 →	+0.319	+3.196	.007	.009	2	5
COAD	CENPK →	+0.561	+2.415	.002	.003	3	4
COAD	CENPH →	+0.537	+3.837	<.001	<.001	3	4
COAD	CTDNEP1 →	+0.399	+3.100	<.001	<.001	3	4
COAD	TXNL1 →	+0.395	+2.252	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,208 associations by consensus.

PSMB6 by ARHGEF17 expression — COAD

Explore this box plot interactively →