Across TCGA cell cohorts, ARHGEF12 mutation is significantly associated with the RNA expression of many other genes, with 648 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF12-associated genes across cancer lineages are HAO1, PRR23A, and MINDY4B. Each is linked with ARHGEF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF12-to-partner and partner-to-ARHGEF12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF12→partner) and Y-score (partner→ARHGEF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HAO1 →	+0.036	+3.378	.008	.006	3	2
BLOOD_Leukemia	PRR23A →	+0.042	+3.269	<.001	.007	3	2
OESOPHAGUS	MINDY4B →	+0.070	+4.906	<.001	.006	3	1
SKIN	C4BPA →	+0.033	+4.054	<.001	.004	3	1
LARGE_INTESTINE	EIF3L →	+0.560	+3.257	.001	.002	3	1
LARGE_INTESTINE	IFT27 →	+0.791	+3.588	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 648 associations by consensus.

Exploration

ARHGEF12 survival (RNA) · tumor vs normal (RNA) · all ARHGEF12 data types