ARHGEF10L

Across TCGA patient cohorts, ARHGEF10L mutation is significantly associated with the RNA expression of many other genes, with 4,716 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF10L-associated genes across cancer lineages are TYW3, ZFYVE19, and MFN2. Each is linked with ARHGEF10L in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF10L-to-partner and partner-to-ARHGEF10L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYW3 grouped by ARHGEF10L-low versus ARHGEF10L-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10L→partner) and Y-score (partner→ARHGEF10L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TYW3 →	+0.523	+3.476	.001	.002	3	4
UCEC	ZFYVE19 →	+0.316	+1.761	.001	.004	3	4
UCEC	MFN2 →	+0.467	+2.502	<.001	<.001	3	4
UCEC	EMC1 →	+0.330	+1.273	.004	.008	3	4
UCEC	MED18 →	+0.480	+2.065	<.001	<.001	3	4
STAD	H3P16 →	+2.478	+3.371	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,716 associations by consensus.

TYW3 by ARHGEF10L expression — STAD

Explore this box plot interactively →