ARHGEF10L

Across TCGA pan-cancer cohorts, ARHGEF10L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARHGEF10L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARHGEF10L RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGEF10L is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where ARHGEF10L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGEF10L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.602	<.001	12	view →
KICH	All	III,IV	−1.571	<.001	11	view →
THCA	Male	All	−0.769	<.001	9	view →
KIRP	All	All	−0.528	<.001	6	view →
BRCA	Female	II,III,IV	−0.335	<.001	6	view →
KIRC	Male	All	−0.468	<.001	5	view →
LIHC	Female	II,III,IV	+0.859	.001	4	view →
UCEC	All	All	−0.491	.025	4	view →
LUSC	Male	All	−0.448	<.001	3	view →
PRAD	All	All	−0.475	<.001	2	view →
STAD	Male	All	+0.687	.043	1	view →
READ	Female	All	+0.552	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARHGEF10L–HNSC

Open the HNSC breakdown →