ARHGEF10L

Across TCGA patient cohorts, ARHGEF10L mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF10L-associated genes across cancer lineages are Smac, eIF4E, and ASNS. Each is linked with ARHGEF10L in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF10L-to-partner and partner-to-ARHGEF10L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by ARHGEF10L-low versus ARHGEF10L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10L→partner) and Y-score (partner→ARHGEF10L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Smac →	+0.360	+2.858	.012	.033	3	3
COAD	eIF4E →	+0.230	+2.334	.002	.018	3	3
STAD	ASNS →	+0.445	+3.321	.032	.010	3	3
COAD	Caspase-7-cleavedD198 →	+1.402	+2.338	<.001	.017	3	3
STAD	FOXO3a_pS318_S321 →	-0.285	-3.300	<.001	.010	3	2
STAD	GSK-3_pS9 →	-0.499	-3.321	.004	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Smac by ARHGEF10L expression — BLCA

Explore this box plot interactively →