ARHGEF10L

Across TCGA cell cohorts, ARHGEF10L mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ARHGEF10L-associated genes across cancer lineages are KSR2, MSH4, and CYP4A11. Each is linked with ARHGEF10L in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF10L-to-partner and partner-to-ARHGEF10L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by ARHGEF10L-low versus ARHGEF10L-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10L→partner) and Y-score (partner→ARHGEF10L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KSR2 →	+0.242	+3.762	.009	.001	3	2
LARGE_INTESTINE	MSH4 →	+0.334	+3.657	<.001	.001	2	3
CNS	CYP4A11 →	+0.117	+3.832	<.001	.005	3	2
OVARY	OR13J1 →	+0.063	+2.959	.005	.002	3	2
OVARY	TPPP2 →	+0.064	+2.657	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	SMYD1 →	+0.012	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

KSR2 by ARHGEF10L expression — BLOOD_Leukemia

Explore this box plot interactively →