ARHGEF10

Across TCGA patient cohorts, ARHGEF10 mutation is significantly associated with the RNA expression of many other genes, with 5,363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF10-associated genes across cancer lineages are CNTROB, TNK1, and CDC25A. Each is linked with ARHGEF10 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF10-to-partner and partner-to-ARHGEF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTROB grouped by ARHGEF10-low versus ARHGEF10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10→partner) and Y-score (partner→ARHGEF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CNTROB →	+0.381	+2.865	.001	.001	3	4
SKCM	TNK1 →	+0.764	+1.797	.003	.008	3	4
UCEC	CDC25A →	+0.440	+1.715	.001	.005	3	4
UCEC	SAAL1 →	+0.406	+2.081	<.001	<.001	3	4
UCEC	ATPAF2 →	+0.385	+2.233	<.001	<.001	3	4
UCEC	PSMA4 →	+0.359	+1.579	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,363 associations by consensus.

CNTROB by ARHGEF10 expression — SKCM

Explore this box plot interactively →