ARHGEF10

Across TCGA cell cohorts, ARHGEF10 mutation is significantly associated with the RNA expression of many other genes, with 672 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF10-associated genes across cancer lineages are MRAP, DAZL, and FAM149A. Each is linked with ARHGEF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF10-to-partner and partner-to-ARHGEF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRAP grouped by ARHGEF10-low versus ARHGEF10-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF10→partner) and Y-score (partner→ARHGEF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MRAP →	+0.041	+4.672	.004	.002	3	2
CNS	DAZL →	+0.120	+4.169	<.001	.001	3	2
BLOOD_Leukemia	FAM149A →	+0.806	+2.376	<.001	.001	3	2
BLOOD_Leukemia	C12orf57 →	+0.964	+1.936	<.001	.004	3	2
BLOOD_Leukemia	RAB3IP →	+1.170	+3.117	<.001	<.001	3	2
BLOOD_Leukemia	TMBIM1 →	-1.572	-2.526	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

MRAP by ARHGEF10 expression — BREAST

Explore this box plot interactively →