ARHGDIG

Across TCGA cell cohorts, ARHGDIG mutation is significantly associated with the mutation status of many other genes, with 1,869 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGDIG-associated genes across cancer lineages are ZNF512B, SEMA3G, and TMEM248. Each is linked with ARHGDIG in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGDIG-to-partner and partner-to-ARHGDIG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF512B grouped by ARHGDIG-low versus ARHGDIG-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGDIG→partner) and Y-score (partner→ARHGDIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF512B →	+4.044	+5.000	.008	.008	1	3
CNS	SEMA3G →	+4.459	+5.277	.005	.005	1	3
BLOOD_Leukemia	TMEM248 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	OC90 →	+5.321	+5.894	.002	.002	1	2
LARGE_INTESTINE	DECR2 →	+4.672	+5.329	<.001	<.001	1	2
BLOOD_Leukemia	NAA80 →	+6.321	+6.321	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,869 associations by consensus.

ZNF512B by ARHGDIG expression — CNS

Explore this box plot interactively →