ARHGDIG

Across TCGA pan-cancer cohorts, ARHGDIG RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ARHGDIG data layer compared with 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ARHGDIG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGDIG expression acts as an unfavorable survival marker, although some lineages such as LGG and KICH show a favorable association.

KIRC, UVM, and ACC are the cancer types where ARHGDIG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.524	0.708	<.001	178	view →
UVM	DFS	Median	All	0.414	0.784	<.001	137	view →
ACC	DFS	Median	All	0.368	0.768	<.001	103	view →
KIRP	OS	Tertile	All	0.616	0.857	<.001	68	view →
LGG	OS	Median	All	0.933	0.858	<.001	42	view →
BLCA	OS	Quartile	II,III,IV	0.639	0.780	.009	40	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.635	.008	34	view →
STAD	OS	Tertile	III,IV	0.402	0.693	.004	31	view →
UCS	DFS	Median	IV	0.475	0.850	.023	28	view →
OV	OS	Tertile	All	0.788	0.897	.002	26	view →
CESC	DFS	Tertile	II,III,IV	0.600	0.848	.004	22	view →
PRAD	DFS	Tertile	All	0.710	0.870	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ARHGDIG–KIRC (DFS)

Open the KIRC breakdown →