ARHGDIA

Across TCGA patient cohorts, ARHGDIA mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGDIA-associated genes across cancer lineages are p90 RSK, PDK1_pS241, and Rad50. Each is linked with ARHGDIA in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGDIA-to-partner and partner-to-ARHGDIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by ARHGDIA-low versus ARHGDIA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGDIA→partner) and Y-score (partner→ARHGDIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.243	+3.009	.015	.019	3	1
UCEC	PDK1_pS241 →	+0.184	+2.833	.040	.034	3	1
UCEC	Rad50 →	-0.320	-3.321	.011	.010	3	1
UCEC	VEGFR2 →	+0.345	+2.179	.026	.034	3	1
UCEC	14-3-3_zeta →	+0.239	+2.827	.027	.035	3	1
UCEC	ERK2 →	+0.254	+3.321	.012	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p90 RSK by ARHGDIA expression — UCEC

Explore this box plot interactively →