ARHGAP8

Across TCGA cell cohorts, ARHGAP8 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP8-associated genes across cancer lineages are BPIFB6, PRAMEF20, and GSG1L2. Each is linked with ARHGAP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP8-to-partner and partner-to-ARHGAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by ARHGAP8-low versus ARHGAP8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP8→partner) and Y-score (partner→ARHGAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	INSRR →	+0.028	+3.584	<.001	.007	3	1
SKIN	ALPI →	+0.008	+3.347	<.001	.005	3	1
SKIN	HIGD2B →	+0.044	+3.966	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

BPIFB6 by ARHGAP8 expression — LARGE_INTESTINE

Explore this box plot interactively →