ARHGAP8

Across TCGA pan-cancer cohorts, ARHGAP8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ARHGAP8’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ARHGAP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARHGAP8 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

BLCA, KIRC, and HNSC are the cancer types where ARHGAP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGAP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.180	<.001	12	view →
KIRC	Female	II,III,IV	−0.748	<.001	12	view →
HNSC	Male	IV	+0.582	<.001	11	view →
COAD	Male	All	+0.604	<.001	8	view →
STAD	All	II,III,IV	+1.020	<.001	7	view →
THCA	Female	II,III,IV	−0.655	<.001	7	view →
CHOL	All	All	+1.452	<.001	4	view →
LUSC	All	All	+0.421	<.001	4	view →
BRCA	All	II,III,IV	+0.303	.020	4	view →
READ	Female	All	+1.046	.008	2	view →
KIRP	All	All	−0.527	<.001	2	view →
PRAD	All	All	+0.422	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ARHGAP8–BLCA

Open the BLCA breakdown →