ARHGAP6

Across TCGA cell cohorts, ARHGAP6 mutation is significantly associated with the RNA expression of many other genes, with 118 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP6-associated genes across cancer lineages are DEFB125, TAS2R9, and ASZ1. Each is linked with ARHGAP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP6-to-partner and partner-to-ARHGAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB125 grouped by ARHGAP6-low versus ARHGAP6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP6→partner) and Y-score (partner→ARHGAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DEFB125 →	+0.019	+4.058	<.001	.009	3	2
URINARY_TRACT	TAS2R9 →	+0.025	+4.050	<.001	.002	3	1
URINARY_TRACT	ASZ1 →	+0.026	+4.378	<.001	<.001	3	1
BLOOD_Leukemia	CRYBB3 →	+0.064	+2.982	.001	.007	3	1
BLOOD_Leukemia	ADAMTS15 →	+0.560	+3.345	.006	.009	3	1
BLOOD_Leukemia	SPACA5 →	+0.102	+3.745	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

DEFB125 by ARHGAP6 expression — BLOOD_Lymphoma

Explore this box plot interactively →