ARHGAP5

Across TCGA cell cohorts, ARHGAP5 mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP5-associated genes across cancer lineages are OR52A5, RCHY1, and MOCOS. Each is linked with ARHGAP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP5-to-partner and partner-to-ARHGAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52A5 grouped by ARHGAP5-low versus ARHGAP5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP5→partner) and Y-score (partner→ARHGAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR52A5 →	+0.009	+4.369	<.001	.008	3	2
LARGE_INTESTINE	RCHY1 →	+0.783	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	MOCOS →	+1.237	+3.321	<.001	.003	3	2
KIDNEY	BSX →	+0.063	+5.000	<.001	.005	3	1
KIDNEY	KRTAP4-7 →	+0.033	+5.000	<.001	.005	3	1
STOMACH	PRAMEF1 →	+0.024	+3.432	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

OR52A5 by ARHGAP5 expression — SOFT_TISSUE

Explore this box plot interactively →