ARHGAP45

Across TCGA patient cohorts, ARHGAP45 mutation is significantly associated with the RNA expression of many other genes, with 4,093 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP45-associated genes across cancer lineages are CPOX, CRYBB2P1, and LINC00865. Each is linked with ARHGAP45 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP45-to-partner and partner-to-ARHGAP45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPOX grouped by ARHGAP45-low versus ARHGAP45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP45→partner) and Y-score (partner→ARHGAP45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CPOX →	+0.550	+2.446	<.001	.001	3	4
UCEC	CRYBB2P1 →	+0.603	+3.871	<.001	<.001	3	4
UCEC	LINC00865 →	-0.710	-2.662	.002	<.001	3	4
HNSC	RNU4-50P →	+0.299	+4.498	<.001	.002	3	3
HNSC	RNU6-1104P →	+0.289	+4.883	<.001	.004	3	3
UCEC	CENPU →	+0.889	+3.354	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,093 associations by consensus.

CPOX by ARHGAP45 expression — UCEC

Explore this box plot interactively →